The ecto-nucleotide pyrophosphatase/phosphodiesterase 2 promotes early osteoblast differentiation and mineralization in stromal stem cells-Reference-Cited by-同舟云学术

The ecto-nucleotide pyrophosphatase/phosphodiesterase 2 promotes early osteoblast differentiation and mineralization in stromal stem cells

Published:2024-03-01 Issue:3 Volume:326 Page:C843-C849
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Tourkova Irina L.¹²,Larrouture Quitterie C.²,Liu Silvia²,Luo Jianhua²,Schlesinger Paul H.³,Blair Harry C.¹²^ORCID

Affiliation:

1. Research Service, VA Medical Centre, Pittsburgh, Pennsylvania, United States

2. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

3. Department of Cell Biology, Washington University, St. Louis, Missouri, United States

Abstract

We report the discovery that the ecto-nucleotide pyrophosphatase/phosphodiesterase, ENPP2, is an important regulator of early differentiation of bone-forming osteoblasts.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00692.2023

Reference27 articles.

1. Support of bone mineral deposition by regulation of pH

2. Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro

3. High capacity Na+/H+ exchange activity in mineralizing osteoblasts

4. Cellular and extracellular matrix of bone, with principles of synthesis and dependency of mineral deposition on cell membrane transport

5. Growth and mineralization of osteoblasts from mesenchymal stem cells on microporous membranes: Epithelial-like growth with transmembrane resistance and pH gradient