Affiliation:
1. Cyrus Tang Medical Institute, Soochow University, Suzhou, China
Abstract
Cardiac KATP channels physically interact with caveolin-3 in caveolae. In this study, we investigated the functional effect of caveolin-3 on KATP channel activity and identified a novel segment (MAD1) in the C-terminus domain of Caveolin-3 that negatively regulates KATP channel surface density and current amplitude by impairing KATP channel recycling. The peptide corresponding to the MAD1 segment abolished the cardioprotective effect of ischemic preconditioning.
Funder
JST | Jiangsu Natural Science Foundation | Basic Research Program of Jiangsu Province
MOST | National Natural Science Foundation of China
Publisher
American Physiological Society
Cited by
1 articles.
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