Cholesterol depletion decreases adhesion of non-small cell lung cancer cells to E-selectin-Reference-Cited by-同舟云学术

Cholesterol depletion decreases adhesion of non-small cell lung cancer cells to E-selectin

Published:2023-08-01 Issue:2 Volume:325 Page:C471-C482
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Mohammadalipour Amina¹^ORCID,Showalter Christian A.²^ORCID,Muturi Harrison T.³,Farnoud Amir M.⁴,Najjar Sonia M.³⁵,Burdick Monica M.²⁴^ORCID

Affiliation:

1. Department of Physics and Department of Biomedical Engineering, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri, United States

2. Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, United States

3. Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States

4. Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, United States

5. Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States

Abstract

This study investigates the effects of cholesterol on the adhesive behaviors of lung cancer cells in recruitment at metastatic sites. Using cholesterol-modulating compounds, we found that reducing cholesterol decreases the adhesion of non-small cell lung cancer (NSCLC) cells while having no significant effect on small cell lung cancer (SCLC) cells. The study suggests that cholesterol regulates NSCLC cell metastasis by redistributing the adhesion proteins on the cells and modulating cells’ membrane fluidity.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

SLU President’s Research Fund

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00197.2020

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