Sodium-glucose cotransporter 1 promotes the biofunctions of perivascular preadipocytes mediated by Akt/mTOR/p70S6K signaling pathway-Reference-Cited by-同舟云学术

Sodium-glucose cotransporter 1 promotes the biofunctions of perivascular preadipocytes mediated by Akt/mTOR/p70S6K signaling pathway

Published:2024-06-01 Issue:6 Volume:326 Page:C1611-C1624
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Liu Zhiquan¹²,Wang Jiayu¹,Tian Peiqing¹,Liu Yixuan³,Xing Liyun¹,Fu Caihua⁴,Huang Xianwei⁵,Liu Ping¹^ORCID

Affiliation:

1. Department of Cardiology, The Second Hospital of Shandong University, Jinan, China

2. Division of Life Sciences and Medicine, Department of Cardiology, the First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China

3. Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

4. Department of Cardiology, Jinan Central Hospital Affiliated Shandong University, Jinan, China

5. Department of Emergency, The First Affiliated Hospital of Xiamen University, Xiamen, China

Abstract

SGLT-1 is expressed in PVPACs and can affect preadipocyte glucolipid metabolism and vascular remodeling. SGLT-1 promotes the biofunctions of PVPACs mediated by Akt/mTOR/p70S6K signaling pathway. Compared with caudal vein or intraperitoneal injection, the external application of lentivirus-based thermal gel around the carotid artery is an innovative attempt at vascular remodeling model, it may effectively avoid the transfection of lentiviral vector into the whole body of mice and the adverse effect on experimental results.

Funder

Science and Technology Innovation Project of Jinan City

MOST | National Natural Science Foundation of China

Project of the Central Government Guides Local Science and Technology Development

Natural fund project of Shandong Province

Major Research and Development Project of Shandong Province

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00606.2023

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