Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton-Reference-Cited by-同舟云学术

Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton

Published:2024-09-01 Issue:3 Volume:327 Page:C634-C645
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Ruane Peter T.¹²,Paterson Isabel¹²,Reeves Beth¹²,Adlam Daman¹²,Berneau Stéphane C.¹²,Renshall Lewis¹²^ORCID,Brosens Jan J.³^ORCID,Kimber Susan J.⁴,Brison Daniel R.¹⁵,Aplin John D.¹²^ORCID,Westwood Melissa¹²^ORCID

Affiliation:

1. Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom

2. Manchester Academic Health Sciences Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

3. Division of Biomedical Sciences, Obstetrics and Gynaecology, Clinical Sciences Research Laboratory, Warwick Medical School, Coventry, United Kingdom

4. Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Michael Smith Building, Manchester, United Kingdom

5. Department of Reproductive Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

Abstract

Understanding how glucose regulates endometrial function will support preconception guidance and/or the development of targeted interventions for individuals living with diabetes wishing to embark on pregnancy. We found that glucose can influence endometrial epithelial cell receptivity to embryo implantation by regulating posttranslational modification of proteins involved in the maintenance of cell polarity. Impaired or inappropriate endometrial receptivity could contribute to fertility and/or early pregnancy complications caused by poor glucose control.

Funder

Diabetes UK

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00559.2023

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