Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction-Reference-Cited by-同舟云学术

Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction

Published:2024-09-01 Issue:3 Volume:327 Page:C571-C586
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Mouton Alan J.¹²^ORCID,Aitken Nikaela M.¹^ORCID,Morato Jemylle G.¹,O’Quinn Katherine R.¹,do Carmo Jussara M.¹²^ORCID,da Silva Alexandre A.¹²^ORCID,Omoto Ana C. M.¹²^ORCID,Li Xuan¹²^ORCID,Wang Zhen¹²^ORCID,Schrimpe-Rutledge Alexandra C.³,Codreanu Simona G.³,Sherrod Stacy D.³,McLean John A.³,Stanford Joshua K.¹,Brown Jordan A.⁴,Hall John E.¹²

Affiliation:

1. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States

2. Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi, United States

3. Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, Tennessee, United States

4. Jackson State University, Jackson, Mississippi, United States

Abstract

Glutamine metabolism is altered in both infarct macrophages and the remote left ventricle (LV) following myocardial infarction (MI). Supplemental glutamine improves LV function following MI while inhibiting glutamine metabolism with BPTES worsens LV function. Supplemental glutamine or BPTES does not impact macrophage immunometabolic phenotypes after MI.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00272.2024

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