The <i>SLC38A5</i>/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment-Reference-Cited by-同舟云学术

The SLC38A5/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment

Published:2023-08-01 Issue:2 Volume:325 Page:C550-C562
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Taurino Giuseppe¹²^ORCID,Chiu Martina¹^ORCID,Bianchi Massimiliano G.¹²,Griffini Erika¹^ORCID,Bussolati Ovidio¹²^ORCID

Affiliation:

1. Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Parma, Italy

2. MRH—Microbiome Research Hub, University of Parma, Parma, Italy

Abstract

The transporter SLC38A5/SNAT5 provides net influx or efflux of glutamine, asparagine, and serine. These amino acids are of particular metabolic relevance in several conditions. Changes in transporter expression or activity have been described in selected types of human cancers, where SNAT5 can mediate amino acid exchanges between tumor and stromal cells, thus providing a potential therapeutic target. This is the first review that recapitulates the characteristics and roles of the transporter in physiology and pathology.

Funder

University of Parma

International Myeloma Foundation

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00169.2023

Reference119 articles.

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