Regulation of renal aquaporin water channels in acute pyelonephritis-Reference-Cited by-同舟云学术

Regulation of renal aquaporin water channels in acute pyelonephritis

Published:2024-05-01 Issue:5 Volume:326 Page:C1451-C1461
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Ernstsen Christina V.¹,Ranieri Marianna²^ORCID,Login Frédéric H.¹^ORCID,Mahmoud Isra K.¹³,Therkildsen Jacob R.⁴,Valenti Giovanna²^ORCID,Praetorius Helle⁴^ORCID,Nørregaard Rikke¹⁵^ORCID,Nejsum Lene N.¹^ORCID

Affiliation:

1. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

2. Department of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy

3. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

4. Department of Biomedicine, Aarhus University, Aarhus, Denmark

5. Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark

Abstract

Acute pyelonephritis (APN) is associated with reduced renal concentration capacity and increased aquaporin-2 (AQP2) excretion. Uropathogenic Escherichia coli (UPEC) mediates changes in the subcellular localization of AQP2 and we show that in vitro, these changes could be elicited by two pathogen-associated molecular patterns (PAMPs), namely, lipopolysaccharide and peptidoglycan. UPEC infection was unaltered by AQP2 expression and the other renal AQPs (AQP1, AQP3, and AQP4) were unaltered in APN.

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00308.2023

Reference44 articles.

1. The management of urinary infections; what have we learned in the past decade?

2. Urinary tract infections: epidemiology, mechanisms of infection and treatment options

3. Urinary Tract Infection Syndromes

4. UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

5. The interaction of urinary tract infection and renal insufficiency