Time-of-day effects on ex vivo muscle contractility following short-term satellite cell ablation

Author:

Kahn Ryan E.12,Lieber Richard L.234ORCID,Meza Guadalupe2,Dinnunhan Fawzan1,Lacham-Kaplan Orly1,Dayanidhi Sudarshan23ORCID,Hawley John A.1ORCID

Affiliation:

1. Exercise and Nutrition Research Program, The Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia

2. Shirley Ryan AbilityLab, Chicago, Illinois, United States

3. Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States

4. Hines VA Medical Center, Maywood, Illinois, United States

Abstract

Muscle isometric torque fluctuates according to time-of-day with such variation owed to molecular clock regulation. Satellite cells (SCs) have recently demonstrated diurnal characteristics related to muscle physiology. In our work, force production was reduced in the presence versus absence of SCs in the morning but, not in the afternoon. Morning-SC+ animals, producing lower force, sustained lesser degrees of injury versus SC counterparts. One potential mechanism underpinning lower forces produced appears to be lower calcium availability.

Funder

HHS | National Institutes of Health

Novo Nordisk Foundation Center for Basic Metabolic Research

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

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