Characterizing the effects of muscle-specific GSK3α/β reduction on murine muscle contractility and metabolism in female mice-Reference-Cited by-同舟云学术

Characterizing the effects of muscle-specific GSK3α/β reduction on murine muscle contractility and metabolism in female mice

Published:2024-03-01 Issue:3 Volume:326 Page:C999-C1009
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Hockey Briana L.¹²,Finch Michael S.³,Braun Jessica L.¹²^ORCID,Mohammad Ahmad³,Maddalena Lucas A.⁴,Vandenboom Rene¹²,Stuart Jeffrey A.⁵^ORCID,Roy Brian D.¹²^ORCID,MacPherson Rebecca E. K.³^ORCID,Fajardo V. A.¹²^ORCID

Affiliation:

1. Department of Kinesiology, Brock University, St. Catharines, Ontario, Canada

2. Centre for Bone and Muscle Health, Brock University, St. Catharines, Ontario, Canada

3. Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

4. Abcellera Biologics, Vancouver, British Columbia, Canada

5. Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada

Abstract

Here we show that partial GSK3 knockdown has minimal effects on whole body metabolism and muscle contractility in female mice. This is partly inconsistent with previous results found in male mice, which reveal a potential influence of biological sex.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Canada Research Chairs

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Ontario Graduate Scholarship

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00398.2023

Reference28 articles.

1. Attenuation of Adverse Effects of Aging on Skeletal Muscle by Regular Exercise and Nutritional Support

2. ATP Consumption by Sarcoplasmic Reticulum Ca2+ Pumps Accounts for 40-50% of Resting Metabolic Rate in Mouse Fast and Slow Twitch Skeletal Muscle

3. Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

4. Tissue-Specific Role of Glycogen Synthase Kinase 3β in Glucose Homeostasis and Insulin Action

5. Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter