Ca2+ storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 23

Author:

Watanabe Daiki1ORCID,Nishi Miyuki2,Liu Feng2,Bian Yuhan2,Takeshima Hiroshi2

Affiliation:

1. Graduate School of Sport and Health Sciences, Osaka University of Health and Sport Sciences, Osaka, Japan

2. Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

Abstract

The function of calcium storage within sarcoplasmic reticulum (SR) plays a pivotal role in influencing the health and disease states of skeletal muscle. In the present study, we demonstrated that mitsgumin 23, a novel non-selective cation channel, modifies SR Ca2+ storage in skeletal muscle fibers. These findings provide valuable insights into the physiological regulation of Ca2+ in skeletal muscle, offering significant potential for uncovering the mechanisms underlying muscle fatigue, muscle adaptation, and muscle diseases.

Funder

MEXT | Japan Society for the Promotion of Science

Nakatomi Foundation

Vehicle Racing Commemorative Foundation

Publisher

American Physiological Society

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