PGC7 regulates H3K27me3 modification by inhibiting the interaction of YY1 with PRC2-Reference-Cited by-同舟云学术

PGC7 regulates H3K27me3 modification by inhibiting the interaction of YY1 with PRC2

Published:2023-07-01 Issue:1 Volume:325 Page:C286-C299
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Hao Weijie¹,Huang Chenyang¹,Liu Defu¹,Xu Hongyu¹,Liu Yingxiang¹,Guan Yian¹,Chen Bingxue¹,Guo Zekun²^ORCID

Affiliation:

1. College of Veterinary Medicine, Northwest A&F University, Yangling, China

2. College of Life Sciences, Northwest A&F University, Yangling, China

Abstract

PGC7 and YY1 interaction inhibits recruitment of PRC2 by YY1. PGC7 promotes AKT and EZH2 interaction to increase pEZH2-S21 level, which weakens YY1 and EZH2 interaction, thereby decreasing H3K27me3 level. In zygotes, the PGC7-deficient and AKT inhibitor MK2206 promote EZH2 to enter the pronuclei, and increase H3K27me3 level in the pronuclei, as well as inhibition of the expression of zygote-activating genes regulated by H3K27me3 in two-cell embryos, which ultimately affects early embryo development.

Funder

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00041.2023

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