TLR9 activation induces immunosuppression and tumorigenesis via PARP1/PD-L1 signaling pathway in oral squamous cell carcinoma-Reference-Cited by-同舟云学术

TLR9 activation induces immunosuppression and tumorigenesis via PARP1/PD-L1 signaling pathway in oral squamous cell carcinoma

Published:2024-02-01 Issue:2 Volume:326 Page:C362-C381
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Ma Liwei¹²³⁴,Qin Niuyu¹²³,Wan Wendong⁵²³,Song Saiwen⁵²³,Hua Siqi⁵²³,Jiang Canhua⁵²³⁴,Li Ning⁵²³⁴,Huang Long⁵²³⁴,Gao Xing⁵²³⁶⁴^ORCID

Affiliation:

1. Department of Oral Medicine, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China

2. Center of Oral and Maxillofacial Cancer (COMAC), Xiangya Hospital, Central South University, Changsha, Hunan, China

3. Institute of Oral Cancer and Precancerous Lesions, Central South University, Changsha, Hunan, China

4. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China

5. Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China

6. Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, Hunan, China

Abstract

In this research, we took PARP1 as the key target to explore its regulatory effect on oral squamous cell carcinoma (OSCC). The key molecular mechanisms involved in its upstream and downstream regulation were elucidated in OSCC cell lines in vitro and tumor-bearing mice in vivo, combined with clinical OSCC tissues.

Funder

Fellowship of China Postdoctoral Science Foundation

Natural Science Foundation of Hunan Province

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00061.2023

Reference38 articles.

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