Mogrol-mediated enhancement of radiotherapy sensitivity in non-small cell lung cancer: a mechanistic study-Reference-Cited by-同舟云学术

Mogrol-mediated enhancement of radiotherapy sensitivity in non-small cell lung cancer: a mechanistic study

Published:2024-06-01 Issue:6 Volume:326 Page:C1753-C1768
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Yin Zhongbo¹,Zhang Xuedong¹,Sun Xiao²,Huo Yunlong³,Ji Nan⁴,Chen Keyan⁵^ORCID

Affiliation:

1. Department of Pathology, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong, China

2. Master Degree Candidate, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning, China

3. Department of Pathology, Shengjing Hospital affiliated to China Medical University, Shenyang, Liaoning, China

4. Department of Docimasiology, Baoan Central Hospital of Shenzhen, China, Shenzhen, Guangdong, China

5. Department of Laboratory Animal Science, China Medical University, Shenyang, Liaoning, China

Abstract

Mogrol enhances non-small cell lung cancer (NSCLC) cell sensitivity to radiotherapy by downregulating USP22 through the ERK/CREB pathway, reducing COX2 expression. These findings highlight mogrol’s potential as an adjunct to improve NSCLC radiotherapy and open avenues for further research and clinical applications.

Funder

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00684.2023

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