The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by a hypertrophic stimulus-Reference-Cited by-同舟云学术

The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by a hypertrophic stimulus

Published:2024-09-01 Issue:3 Volume:327 Page:C516-C524
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Cui Minying¹,Jannig Paulo¹^ORCID,Halladjian Maral²,Figueiredo Vandré C.³^ORCID,Wen Yuan⁴⁵⁶^ORCID,Vechetti Ivan J.⁷^ORCID,Krogh Nicolai²,Jude Baptiste¹^ORCID,Edman Sebastian¹,Lanner Johanna⁸^ORCID,McCarthy John⁴⁵^ORCID,Murach Kevin A.⁹^ORCID,Sejersen Thomas¹¹⁰¹¹,Nielsen Henrik²,von Walden Ferdinand¹¹¹^ORCID

Affiliation:

1. Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden

2. Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark

3. Department of Biological Sciences, Oakland University, Rochester, Michigan, United States

4. Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States

5. Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States

6. Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States

7. Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States

8. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

9. Department of Health, Human Performance, and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States

10. Department of Child Neurology, Karolinska University Hospital, Astrid Lindgren Children’s Hospital, Stockholm, Sweden

11. Center for Neuromusculoskeletal Restorative Medicine, Hong Kong Science Park, Hong Kong, People’s Republic of China

Abstract

Ribosomal RNAs (rRNAs) are posttranscriptionally modified by 2′ O-methyl (2′- O-Me). This study applied RiboMeth-seq (RMS) to detect changes in 2′- O-Me levels during skeletal muscle hypertrophy, uncovering transient diversification of the ribosome pool in skeletal muscle fibers. This work implies a role for ribosome heterogeneity in skeletal muscle growth and adaptation.

Funder

NEYE-Foundation

AFM-Telethon

Åke Wiberg Stiftelse

Carlsbergfondet

Centrum för idrottsforskning

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

HHS | NIH | National Institute on Aging

HHS | National Institutes of Health

MOST | NSFC | Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao

Sveriges Läkarförbund

Vetenskapsrådet