SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway-Reference-Cited by-同舟云学术

SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway

Published:2024-02-01 Issue:2 Volume:326 Page:C386-C399
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Hu Tao¹²^ORCID,Shi Zhongming²,Sun Yongjin²,Hu Feng³,Rong Yuluo²,Wang Jia²,Wang Liang²,Xu Wenbin²,Zhang Feng²,Zhang Wen-Zhi¹^ORCID

Affiliation:

1. Department of Orthopedics, Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China

2. Division of Life Sciences and Medicine, Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, People’s Republic of China

3. Department of Orthopedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China

Abstract

Selenophosphate synthetase 1 (SEPHS1) deficiency leads to an increase in reactive oxygen species levels and in the subsequent activation of the Hippo-Yap/Taz signaling pathway. In the rat model of intervertebral disc degeneration (IVDD), overexpression of SEPHS1 and inhibition of Hippo-YAP/Taz mitigated the progression of disc degeneration indicating the involvement of SEPHS1 in IVDD. SEPHS1 is a promising therapeutic target for IVDD.

Funder

安徽省科学技术厅 | Natural Science Foundation of Anhui Province

Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00571.2023

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