Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy-Reference-Cited by-同舟云学术

Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy

Published:2024-03-01 Issue:3 Volume:326 Page:C724-C741
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Wu Haowei¹,Zhang Peipei²,Zhou Jiedong¹,Hu Songqing¹,Hao Jinjin¹,Zhong Zuoquan³,Yu Haijun¹,Yang Juntao¹,Chi Jufang⁴^ORCID,Guo Hangyuan¹

Affiliation:

1. School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China

2. Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China

3. The First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China

4. Department of Cardiology, Zhuji People’s Hospital, Shaoxing, Zhejiang, People’s Republic of China

Abstract

This study demonstrated for the first time that paeoniflorin (PA) exerts protective effects in diabetic cardiomyopathy mice by alleviating myocardial damage, resisting ferroptosis, and changing the community composition and structure of the intestinal microbiota, and 11,12-epoxyeicosatrienoic acid (11,12-EET) may serve as a key contributor in its therapeutic efficacy.

Funder

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00565.2023

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