Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy-Reference-Cited by-同舟云学术

Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy

Published:2023-07-01 Issue:1 Volume:325 Page:C332-C343
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Becker Lucas¹²,Montes-Mojarro Ivonne A.³,Layland Shannon Lee¹^ORCID,Nsair Ali⁴,Fend Falko³^ORCID,Marzi Julia¹²⁵^ORCID,Schenke-Layland Katja¹²⁵^ORCID

Affiliation:

1. Department for Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, University of Tübingen, Tübingen, Germany

2. Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tübingen, Tübingen, Germany

3. Institute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany

4. Division of Cardiology, Department of Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, California, United States

5. NMI Natural and Medical Sciences Institute at the University Tübingen, Reutlingen, Germany

Abstract

Cardiomyopathies are associated with severe fibrotic remodeling of the heart, which is characterized by the excessive accumulation of collagen type I (COL I). In this study, we used marker-independent Raman microspectroscopy (RMS) to gain a deeper understanding of the disease’s underlying molecular and cellular mechanisms.

Funder

Deutsche Forschungsgemeinschaft

Ministerium für Wirtschaft, Arbeit und Wohnungsbau Baden-Württemberg

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00209.2023

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