Affiliation:
1. State Key Laboratory of OphthalmologyZhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouChina
Abstract
Our study explores zinc’s pivotal role in mitigating extracellular matrix dysregulation in the trabecular meshwork and glucocorticoid-induced ocular hypertension. We found that in human trabecular meshwork cells treated with dexamethasone, intracellular Zn2+ significantly decreased, accompanied by impaired extracellular Zn2+ uptake. Zinc supplementation rescues visual function by modulating extracellular matrix proteins and lowering intraocular pressure, offering a direction for further exploration in glaucoma management.
Funder
GDSTC | Natural Science Foundation of Guangdong Province
GZST | Natural Science Foundation of Guangzhou Municipality
MOST | National Key Research and Development Program of China
MOST | National Natural Science Foundation of China
State Key Laboratory of Ophthalmology
Publisher
American Physiological Society