The utility—and limitations—of the rodent synergist ablation model in examining mechanisms of skeletal muscle hypertrophy

Abstract

In this issue, Burke et al. discuss the utility of the rodent synergist ablation (SA) model for examining mechanisms associated with skeletal muscle hypertrophy. In this invited perspective, we aim to complement their original perspective by discussing limitations to the model along with alternative mechanical overload models that have strengths and limitations.