Mechanics and energetics of muscle contraction in normal and dystrophic chickens

Author:

Polinski W. J.,Rall J. A.

Abstract

Energy liberation and isometric force generation were compared at 25 degrees C in isolated normal (n = 15) and dystrophic (n = 18) posterior latissimus dorsi muscles (PLD) from 16- to 33-day-old chickens. Twitch-energy liberation in dystrophic muscle decreased by 27 +/- 6%, and force per cross-sectional area decreased by 26 +/- 11%. Tetanic energy liberation in dystrophic PLD was depressed by 32 +/- 10% compared with a 22 +/- 9% reduction in peak force per cross-sectional area plus a 26 +/- 3% reduction in ability to maintain force. Normalizing results using the force-time integral demonstrates an unaltered force generation per unit energy liberation in dystrophic PLD (7 +/- 11% difference from normal). Kinetic properties of the mechanical responses were not significantly different in normal compared with dystrophic PLD. Dystrophic PLD demonstrated hyperexcitability to nerve transection and electrical stimulation. Although force-generating capacity is reduced in dystrophic PLD, coupling of force production to energy utilization appears unaltered.

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Cited by 29 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3