SIRT4 promotes neuronal apoptosis in models of Alzheimer’s disease via the STAT2–SIRT4

SIRT4 promotes neuronal apoptosis in models of Alzheimer’s disease via the STAT2–SIRT4–mTOR pathway

Published:2024-06-01 Issue:6 Volume:326 Page:C1697-C1709
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Xing Dianxia¹²,Zhang Wenjin³,Cui Wei³,Yao Xiuya³,Xiao Yaping⁴,Chen Lihua¹,Yuan Shiyun¹,Duan Yanyan⁵,Yu Weihua⁶,Pan Pengfei⁷,Lü Yang¹^ORCID

Affiliation:

1. Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

2. Department of Geriatrics, Chongqing University Three Gorges Hospital, Chongqing, China

3. Central Laboratory of Chongqing University Three Gorges Hospital, Chongqing, China

4. Department of Pharmacy and Pharmacology, Chongqing University Three Gorges Hospital, Chongqing, China

5. College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China

6. Institute of Neuroscience, Chongqing Medical University, Chongqing, China

7. Intensive Care Unit, Chongqing University Three Gorges Hospital, Chongqing, China

Abstract

The study reveals that in Alzheimer’s disease models, SIRT4 expression increases, contributing to neuronal apoptosis and amyloid-β deposition. Reducing SIRT4 lessens apoptosis and amyloid-β accumulation, improving memory in mice. This process involves the mTOR pathway, regulated by STAT2 transcription factor. These findings suggest targeting the STAT2-SIRT4-mTOR axis as a potential Alzheimer’s treatment strategy.

Funder

Science and Technology Bureau of Wanzhou, Chongqing

CSTC | Chongqing Science and Technology Foundation

Chongqing Municipal Education Commission

Fundamental Research Funds for the Key Research Program of Chongqing Science and Technology Commission

Science and Technology Bureau of Wanzhou District, Chongqing

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00012.2024

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