Hyaluronan network: a driving force in cancer progression-Reference-Cited by-同舟云学术

Hyaluronan network: a driving force in cancer progression

Published:2022-07-01 Issue:1 Volume:323 Page:C145-C158
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Karalis Theodoros¹,Skandalis Spyros S.¹^ORCID

Affiliation:

1. Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece

Abstract

Hyaluronan is one of the most abundant macromolecules of the extracellular matrix and regulates several physiological cell and tissue properties. However, hyaluronan has been shown to accumulate together with its receptors in various cancers. In tumors, accumulation of hyaluronan system components (hyaluronan synthesizing/degrading enzymes and interacting proteins) associates with poor outcomes for the patients. In this article, we review the main roles of hyaluronan in normal physiology and cancer and further discuss the targeting of hyaluronan system as an applicable therapeutic strategy.

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00139.2022

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