Affiliation:
1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States
Abstract
With an aging population, lung fibrotic diseases are becoming a global health burden. Dysfunctional repair of the alveolar epithelium is a key causative process that initiates lung fibrosis. Normal alveolar regeneration relies on functional progenitor cells; however, the senescence of these cells, which increases with age, hinders their ability to contribute to repair. Here, we discuss studies on the control and consequence of progenitor cell senescence in fibrosis and opportunities for research.
Funder
HHS | NIH | National Institute on Aging
Foundation for the National Institutes of Health
Francis Family Foundation
HHS | NIH | National Heart, Lung, and Blood Institute
UC | UCLA | Clinical and Translational Science Institute, University of California, Los Angeles
Publisher
American Physiological Society
Cited by
1 articles.
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