Differential metabolic secretion between muscular dystrophy mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development-Reference-Cited by-同舟云学术

Differential metabolic secretion between muscular dystrophy mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development

Published:2024-07-01 Issue:1 Volume:327 Page:C34-C47
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Niba Emma Tabe Eko¹²^ORCID,Awano Hiroyuki³,Nishimura Noriyuki⁴,Koide Hiroshi¹,Matsuo Masafumi⁵,Shinohara Masakazu²⁶^ORCID

Affiliation:

1. Laboratory of Molecular and Biochemical Research, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan

2. Division of Molecular Epidemiology, Kobe University Graduate School of Medicine, Kobe, Japan

3. Organization for Research Initiative and Promotion, Research Initiative Center, Tottori University, Yonago, Japan

4. Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan

5. Graduate School of Science, Technology and Innovation , Kobe University, Kobe, Japan

6. The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe, Japan

Abstract

To the best of our knowledge, SCS has rarely been identified in patients with DMD or mdx mice. We observed that RMS and SCS tumors that spontaneously developed from mdx mice with the same Dmd genetic background exhibited differences in metabolic secretion. We proposed that, in addition to dystrophin deficiency, the levels of secreted metabolites may play a role in the determination of tumor-type development in a Dmd-deficient background.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00523.2023

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