Metformin mitigates adipogenesis of fibro-adipogenic progenitors after rotator cuff tears via activating mTOR/ULK1-mediated autophagy-Reference-Cited by-同舟云学术

Metformin mitigates adipogenesis of fibro-adipogenic progenitors after rotator cuff tears via activating mTOR/ULK1-mediated autophagy

Published:2024-06-01 Issue:6 Volume:326 Page:C1590-C1603
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Zhou Hao¹^ORCID,Lin Xingzuan¹,Feng Shujing²,Zhu Siyuan³,Zhou Han¹,Chen Huifang²,Youwu He⁴,Wang Zekai⁵,Wang Ru²,Shao Xiexiang¹,Wang Jianhua¹^ORCID

Affiliation:

1. Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

2. Department of Sports Medicine, School of Exercise and Health, Shanghai University of Sport, Shanghai, People’s Republic of China

3. Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China

4. Department of Hand Plastic Surgery, The First People’s Hospital of Linping District, Hangzhou, People’s Republic of China

5. Department of Life Science, University of Toronto, Toronto, Ontario, Canada

Abstract

The current study demonstrated that gender-specific disparities in muscular fatty infiltration are attributed to mTOR/ULK1-mediated autophagy of FAPs. Decreased autophagic activity contributes to adipogenic differentiation in female FAPs after RCT. Moreover, metformin could enhance mTOR/ULK1-mediated autophagic processes of FAPs, thereby alleviating fatty infiltration and improving shoulder functionality after RCT. Therefore, metformin could be a promising noninvasive intervention to ameliorate muscular fatty infiltration of RCT.

Funder

science and technology planning project of Linpin

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00034.2024

Reference41 articles.

1. Rotator cuff tear degeneration and the role of fibro‐adipogenic progenitors

2. Fatty Infiltration Is a Prognostic Marker of Muscle Function After Rotator Cuff Tear

3. Obesity and sex influence fatty infiltration of the rotator cuff: the Rotator Cuff Outcomes Workgroup (ROW) and Multicenter Orthopaedic Outcomes Network (MOON) cohorts

4. Correlation of atrophy and fatty infiltration on strength and integrity of rotator cuff repairs: A study in thirteen patients

5. Fatty Infiltration and Atrophy of the Rotator Cuff do not Improve after Rotator Cuff Repair and Correlate with Poor Functional Outcome

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Novel perspectives on autophagy-oxidative stress-inflammation axis in the orchestration of adipogenesis;Frontiers in Endocrinology;2024-06-24