Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats-Reference-Cited by-同舟云学术

Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats

Published:2022-08-01 Issue:2 Volume:323 Page:G126-G133
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Kim Joohyun¹^ORCID,Yang Yongqiang¹,Hong Seung-Keun¹,Zielonka Jacek²,Dash Ranjan K.³⁴,Audi Said H.³⁴^ORCID,Kumar Suresh N.⁵,Joshi Amit³⁴,Zimmerman Michael A.¹,Hong Johnny C.¹

Affiliation:

1. Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin

2. Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin

3. Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin

4. Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin

5. Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin

Abstract

Previous attempts to use fluorophore clearance to test liver function have relied on a single source of data. However, the kinetics of substrate processing via bile metabolism include decreasing levels in blood and increasing levels in bile. Thus, we analyzed data from blood and bile to better reflect fluorescein clearance kinetics.

Funder

The Kevin T. Cottrell Memorial Fund for Organ Transplantation, Medical College of Wisconsin

The J. Scott Harkness Organ Transplantation Research and Education Fund, Medical College of Wisconsin

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00038.2022

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