Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids-Reference-Cited by-同舟云学术

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids

Published:2021-04-01 Issue:4 Volume:320 Page:G617-G626
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Fujiwara Yuta¹,Yamane Shunsuke¹,Harada Norio¹,Ikeguchi-Ogura Eri¹,Usui Ryota¹,Nakamura Toshihiro¹,Iwasaki Kanako¹,Suzuki Kazuyo¹,Yabe Daisuke²^ORCID,Hayashi Yoshitaka³,Inagaki Nobuya¹

Affiliation:

1. Department of Diabetes, Endocrinology, and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

2. Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan

3. Department of Endocrinology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

Abstract

This study focused on the physiological significance of carbonic anhydrase 8 (CAR8) in GLP-1 secretion from enteroendocrine preproglucagon (PPG)-expressing cells. We found an inhibitory role of CAR8 in LCFA-induced GLP-1 secretion in vitro and in vivo, suggesting a novel therapeutic approach to diabetes and obesity through augmentation of postprandial GLP-1 secretion by CAR8 inhibition.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00312.2020

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