Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis-Reference-Cited by-同舟云学术

Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis

Published:2021-04-01 Issue:4 Volume:320 Page:G658-G674
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Weis Victoria G.¹,Deal Anna C.¹,Mekkey Gehad¹²,Clouse Cara¹,Gaffley Michaela¹³,Whitaker Emily¹,Peeler Cole B.¹⁴,Weis Jared A.⁴⁵⁶,Schwartz Marshall Z.¹,Atala Anthony¹

Affiliation:

1. Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina

2. Faculty of Science, Zagazig University, Zagazig, Egypt

3. General Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina

4. School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, Virginia

5. Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, North Carolina

6. Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina

Abstract

These studies demonstrate a human placental-derived stem cell (hPSC) therapeutic strategy for necrotizing enterocolitis (NEC). In an experimental model of NEC, hPSC administration improved macroscopic intestinal health, ameliorated epithelial morphology, and supported the intestinal stem cell niche. Our data suggest that hPSC are a potential therapeutic approach to attenuate established intestinal NEC damage. Further, we show hPSC are a novel research tool that can be utilized to elucidate critical neonatal repair mechanisms to overcome NEC.

Funder

State of North Carolina

Lisa Dean-Moseley Foundation

HHS | NIH | National Cancer Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00369.2020

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