NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models-Reference-Cited by-同舟云学术

NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models

Published:2022-01-01 Issue:1 Volume:322 Page:G142-G153
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Stepanov Yurii V.¹,Golovynska Iuliia¹,Dziubenko Nataliia V.²,Kuznietsova Halyna M.²,Petriv Nataliia³,Skrypkina Inessa⁴,Golovynskyi Sergii¹^ORCID,Stepanova Liudmyla I.³,Stohnii Yevhenii³,Garmanchuk Liudmyla V.³,Ostapchenko Liudmyla I.³,Yevsa Tetyana³^ORCID,Qu Junle¹,Ohulchanskyy Tymish Y.¹^ORCID

Affiliation:

1. Center for Biomedical Optics and Photonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, People’s Republic of China

2. Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

3. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

4. Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Abstract

We have shown NMDAR expression in cell transformation process at early stages of cancer, specifically HCC. The aim of our study was to define the disease stages from precancerous liver disease towards liver cancer progression when NMDAR subunits were expressed/detected. A fibrosis/HCC rat model, immunohistochemistry combined with epifluorescence microscopy imaging, Western blotting was used. The dynamics of appearance of NMDAR subunits, their expression and methylation status during the development of HCC were shown and discussed.

Funder

NSFC | National Natural Science Foundation of China-Yunnan Joint Fund

Shenzhen Fundamental Research Program

Deutsche Forschungsgemeinschaft

Project of Department of Education of Guangdong Province

Ministry of Education and Science of Ukraine

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00060.2021