Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor-Reference-Cited by-同舟云学术

Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor

Published:2023-04-01 Issue:4 Volume:324 Page:G305-G321
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Breznik Jessica A.¹²³^ORCID,Jury Jennifer⁴⁵,Verdú Elena F.⁴⁵,Sloboda Deborah M.⁴⁵⁶⁷,Bowdish Dawn M. E.¹²³^ORCID

Affiliation:

1. McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

2. Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

3. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

4. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

5. Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada

6. Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada

7. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada

Abstract

We found that diet-induced obesity in female mice has tissue- and time-dependent effects on intestinal paracellular permeability as well as monocyte-derived and tissue-resident macrophage numbers, surface marker phenotype, and intracellular production of the cytokines IL-10 and TNF. These changes were not mediated by TNF.

Funder

McMaster University

Government of Ontario

Gouvernement du Canada | Canadian Institutes of Health Research

Canada Research Chairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00231.2022

Reference97 articles.