K<sub>V</sub>7 but not dual small and intermediate K<sub>Ca</sub> channel openers inhibit the activation of colonic afferents by noxious stimuli-Reference-Cited by-同舟云学术

K_V7 but not dual small and intermediate K_Ca channel openers inhibit the activation of colonic afferents by noxious stimuli

Published:2023-11-01 Issue:5 Volume:325 Page:G436-G445
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Bhebhe Charity N.¹,Higham James P.¹,Gupta Rohit A.¹,Raine Tim²,Bulmer David C.¹^ORCID

Affiliation:

1. Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

2. Department of Gastroenterology, Addenbrookes Hospital, Cambridge University Teaching Hospitals, Cambridge, United Kingdom

Abstract

Despite marked coexpression of small ( Kcnn1, Kcnn2) and intermediate ( Kcnn4) conductance calcium-activated potassium channel transcripts with P2X3 ( P2rx3) or bradykinin B2 ( Bdkrb2) receptors in colonic sensory neurons, pharmacological activation of these channels had no effect on the colonic afferent response to ATP, bradykinin or luminal distension of the colon. This is in contrast to the robust inhibitory effect of the KV7 channel opener, retigabine.

Funder

Gate Cambridge Trust

Crohn's and Colitis UK

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00141.2023

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