Oral administration of CXCL12-expressing <i>Limosilactobacillus reuteri</i> improves colitis by local immunomodulatory actions in preclinical models-Reference-Cited by-同舟云学术

Oral administration of CXCL12-expressing Limosilactobacillus reuteri improves colitis by local immunomodulatory actions in preclinical models

Published:2024-08-01 Issue:2 Volume:327 Page:G140-G153
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Öhnstedt Emelie¹²^ORCID,Doñas Cristian¹,Parv Kristel¹,Pang Yanhong¹,Lofton Tomenius Hava¹²,Carrasco López Macarena¹,Gannavarapu Venkata Ram²,Choi Jacueline²,Ovezik Maria²,Frank Peter¹,Jorvid Margareth¹,Roos Stefan³,Vågesjö Evelina¹²^ORCID,Phillipson Mia²⁴^ORCID

Affiliation:

1. Ilya Pharma AB, Uppsala, Sweden

2. Division of Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

3. Department of Molecular Sciences, Swedish University of Agriculture, Uppsala, Sweden

4. The Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Abstract

Colitis symptoms are efficiently reduced by peroral administration of probiotic bacteria genetically modified to deliver CXCL12 locally to the inflamed intestine in several mouse models.

Funder

Ilya Pharma AB

BioX grant from STUND to Ilya Pharma

Knut och Alice Wallenbergs Stiftelse

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00022.2024

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