Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity-Reference-Cited by-同舟云学术

Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity

Published:2023-04-01 Issue:4 Volume:324 Page:G250-G261
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Barker Katie H.¹,Higham James P.¹,Pattison Luke A.¹,Chessell Iain P.²,Welsh Fraser²,Smith Ewan St. J.¹^ORCID,Bulmer David C.¹^ORCID

Affiliation:

1. Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

2. Department of Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

Abstract

The pro-inflammatory cytokine interleukin-13 (IL-13) is elevated in gastrointestinal (GI) diseases. This study confirms a role for IL-13 in colonic afferent sensitization and defines a role for downstream Janus kinase (JAK) and p38 MAPK signaling in colonic mechanosensitization. It is shown that IL-13-mediated increase in [Ca2+]i in capsaicin-sensitive sensory neurons is dependent on p38 MAPK, and JAK signaling and IL-13-induced sensitization of colonic afferents to noxious mechanical distension is abolished by inhibition of p38 MAPK and JAK.

Funder

AstraZeneca

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00280.2022

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