Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs-Reference-Cited by-同舟云学术

Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs

Published:2021-02-01 Issue:2 Volume:320 Page:G227-G239
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Yakah William¹,Singh Pratibha²,Brown Joanne²,Stoll Barbara³,Burrin Doug³^ORCID,Premkumar Muralidhar H.⁴,Otu Hasan H.⁵,Gu Xuesong⁶,Dillon Simon T.⁶,Libermann Towia A.⁶,Freedman Steven D.²⁷,Martin Camilia R.¹⁷

Affiliation:

1. Department of Neonatology Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

2. Division of Gastroenterology Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

3. United States Department of Agriculture-Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas

4. Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas

5. Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska

6. Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

7. Division of Translational Research Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

Abstract

Exposure to parenteral lipid emulsions induces unique intestinal fatty acid and metabolomic profiles; however, these profiles are not linked to a difference in NEC risk in preterm pigs. Metabolomic and proteomic analyses provide mechanistic insights into NEC pathogenesis. Compared with healthy ileal tissue, metabolites in tryptophan metabolism and arachidonic acid-containing glycerophospholipids are increased in NEC tissue. Proteomic analysis differentiates NEC versus no NEC in the domains of tissue injury, glucose uptake, and chemokine signaling.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

USDA | National Institute of Food and Agriculture

Charles H. Hood Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00311.2020

Reference57 articles.

1. Necrotizing Enterocolitis