Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon-Reference-Cited by-同舟云学术

Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon

Published:2024-02-01 Issue:2 Volume:326 Page:G176-G186
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

King James W.¹²,Bennett Aidan S. W.¹³,Wood Hannah M.¹³,Baker Corey C.¹,Alsaadi Hanin⁴,Topley Max⁴,Vanner Stephen A.¹²,Reed David E.¹²,Lomax Alan E.¹²³^ORCID

Affiliation:

1. Gastrointestinal Diseases Research Unit, Queen’s University, Kingston, Ontario, Canada

2. Department of Medicine, Queen’s University, Kingston, Ontario, Canada

3. Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada

4. Centre for Neuroscience Studies, Queen’s University, Kingston, Ontario, Canada

Abstract

This is the first study to characterize TRPM3 protein expression and function in colon-projecting DRG neurons. A TRPM3 agonist excited DRG neurons and colonic afferent nerves from healthy mice. TRPM3 agonist responses in DRG neurons were elevated during colitis. Inhibiting TRPM3 reduced the firing of wide dynamic range afferent nerves from mice with colitis but had no effect in control mice.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00230.2023

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