Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function-Reference-Cited by-同舟云学术

Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function

Published:2022-03-01 Issue:3 Volume:322 Page:G368-G382
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Sampath Chethan¹,Raju Abhinav V.²,Freeman Michael L.³,Srinivasan Shanthi²⁴,Gangula Pandu R.¹^ORCID

Affiliation:

1. Department of ODS and Research, School of Dentistry, Meharry Medical College, Nashville, Tennessee

2. Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia

3. Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee

4. Atlanta Veterans Affairs Health Care System, Atlanta, Georgia

Abstract

Primary neuronal cell crust (pENCs) in the intestine habitats nNOS and Nrf2, which was suppressed in diabetic gastroparesis. Activation of Nrf2 restored nNOS by suppressing inflammatory markers in pENCs cells. Inhibition of Nrf2 reveals a negative feedback mechanism for the activation of GSK-3. Activation of Nrf2 alleviates STZ-induced delayed gastric emptying and nitrergic relaxation in female mice. Activation of Nrf2 restored impaired gastric BH4 biosynthesis enzyme GCH-1, nNOSα expression thus regulating nitric oxide levels.

Funder

Research Centers in Minority Institutions (RCMI) Infrastructure Core

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00323.2021

Reference72 articles.

1. The enteric nervous system and neurogastroenterology

2. Diabetes and the enteric nervous system

3. Diabetic gastrointestinal motility disorders and the role of enteric nervous system: Current status and future directions

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