Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study-Reference-Cited by-同舟云学术

Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study

Published:2022-11-01 Issue:5 Volume:323 Page:G428-G438
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Greer Phil J.¹,Lee Peter J.²^ORCID,Paragomi Pedram³,Stello Kim³,Phillips Anna³,Hart Phil²,Speake Cate⁴,Lacy-Hulbert Adam⁵,Whitcomb David C.¹³⁶⁷^ORCID,Papachristou Georgios I.²

Affiliation:

1. Ariel Precision Medicine, Pittsburgh, Pennsylvania

2. Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio

3. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

4. Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington

5. Center for Fundamental Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington

6. Department of Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania

7. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

In this study, we showed that the proinflammatory cytokine response in SAP is an early event, with subsequent downregulation of proinflammatory cytokines beginning at day 1 of symptom onset. Our findings underscore the importance of enrolling subjects very early in the disease course when conducting studies to investigate early immune events of SAP; this current study also serves as an important reference for the design of future biomarker studies and therapeutic trials in SAP.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Defense

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00100.2022

Reference49 articles.

1. Global epidemiology and holistic prevention of pancreatitis