Effect of knocking out mouse <i>Slc44a4</i> on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology-Reference-Cited by-同舟云学术

Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology

Published:2024-07-01 Issue:1 Volume:327 Page:G36-G46
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Sabui Subrata¹²,Anthonymuthu Selvaraj¹^ORCID,Ramamoorthy Kalidas¹,Skupsky Jonathan²³,Jennings Tara Sinta Kartika⁴,Rahmatpanah Farah⁴,Fleckenstein James M.⁵⁶,Said Hamid M.¹²³^ORCID

Affiliation:

1. Department of Physiology and Biophysics, University of California, Irvine, California, United States

2. Veterans Affairs Medical Center, Long Beach, California, United States

3. Department of Medicine, University of California, Irvine, California, United States

4. Department of Pathology and Laboratory Medicine, University of California, Irvine, California, United States

5. Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States

6. Veterans Affairs Medical Center, St. Louis, Missouri, United States

Abstract

This study shows that Slc44a4 is the predominant or only transport system involved in the uptake of the gut microbiota-generated thiamine pyrophosphate (TPP) in the colon and that its deletion affects colon physiology and increases its susceptibility to inflammation.

Funder

Washington University Digestive Diseases Research Center

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00065.2024

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