Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function-Reference-Cited by-同舟云学术

Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function

Published:2021-04-01 Issue:4 Volume:320 Page:G420-G438
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Goggins Bridie J.¹²³⁴^ORCID,Minahan Kyra¹²³⁴,Sherwin Simonne¹²³⁴,Soh Wai S.¹²³⁴,Pryor Jennifer¹²³⁴,Bruce Jessica¹²³⁴,Liu Gang¹²³⁴^ORCID,Mathe Andrea¹²³⁴,Knight Darryl¹²,Horvat Jay C.¹²,Walker Marjorie M.²⁴,Keely Simon¹²³⁴^ORCID

Affiliation:

1. School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia

2. Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

3. Gastrointestinal Research Group, University of Newcastle, New South Wales, Australia

4. Priority Research Centre for Digestive Health and Neurogastroenterology, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia

Abstract

HIF-1 plays an important role in epithelial restitution, selectively inducing integrins α6 and α2 to promote migration and proliferation, respectively. HIF-stabilizing prolyl-hydroxylase inhibitors accelerate intestinal mucosal healing by inducing epithelial integrin expression.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00192.2020

Reference77 articles.

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