Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics-Reference-Cited by-同舟云学术

Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics

Published:2023-12-01 Issue:6 Volume:325 Page:G556-G569
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Mims Tahliyah S.¹,Kumari Roshan²,Leathem Cameron¹,Antunes Karen¹,Joseph Sydney³,Yen Mei-I¹,Ferstl Danielle¹,Jamieson Sophia M.¹,Sabbar Austin¹,Biebel Claudia¹,Lazarevic Nikolai¹,Willis Nathaniel B.¹,Henry Lydia²,Yen Chi-Liang E.¹^ORCID,Smith Joseph P.⁴,Gosain Ankush⁵,Meisel Marlies⁶,Willis Kent A.⁷^ORCID,Talati Ajay J.²^ORCID,Elabiad Mohammad. T.²,Hibl Brianne⁸,Pierre Joseph F.¹⁹^ORCID

Affiliation:

1. Department of Nutritional Sciences, College of Agriculture and Life Science, University of Wisconsin-Madison, Madison, Wisconsin, United States

2. Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States

3. Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States

4. Department of Pharmacy, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin, United States

5. Department of Pediatric Surgery, Children’s Hospital of Colorado, Denver, Colorado, United States

6. Department of Immunology, University of Pittsburg, Pittsburg, Pennsylvania, United States

7. Division of Neonatology, Department of Pediatrics, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, United States

8. Department of Comparative Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States

9. Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States

Abstract

This study successfully established a translationally relevant, murine neonatal parenteral nutrition (PN) model. Short-term PN is sufficient to induce hepatitis-associated cholestasis in a neonatal murine model that can be used to understand disease in early life. The administration of antibiotics during PN protects animals from bacterial translocation and proinflammatory responses but induces unique metabolic shifts that may predispose the liver toward early steatosis.

Funder

HHS | NIH | NCI | Basic Research Laboratory

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00129.2023

Reference44 articles.

1. Total parenteral nutrition adversely affects gut barrier function in neonatal piglets

2. Parenteral Nutrition–Associated Liver Disease

3. Parenteral nutrition suppresses the bactericidal response of the small intestine

4. Parenteral nutrition increases susceptibility of ileum to invasion by E coli