Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice

Abstract

Influenza A virus (IAV) infection during pregnancy is associated with changes in gut-associated lymphoid tissue (GALT) in the offspring in a region-dependent manner. Neutrophils and monocytes/macrophages were elevated in the cecal patch of offspring from infected dams. This increase in innate immune cell infiltration was not observed in the Peyer’s patches. T cells were also elevated in the cecal patch but not in the Peyer’s patches.