Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes-Reference-Cited by-同舟云学术

Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes

Published:2021-08-01 Issue:2 Volume:321 Page:G113-G122
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Jomura Ryuta¹,Tanno Yu¹,Akanuma Shin-ichi¹,Kubo Yoshiyuki¹,Tachikawa Masanori²,Hosoya Ken-ichi¹

Affiliation:

1. Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

2. Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

Abstract

Our study is the first to identify the role of monocarboxylate transporter 12 (MCT12) as a transporter of creatine (Cr) in the liver. MCT12 was found to significantly contribute to the efflux of Cr on the sinusoidal membrane of the hepatocytes. Since hepatocytes are known to be involved in creatine biosynthesis. The present findings can be beneficial for the regulation of Cr biosynthesis and supply.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00143.2021

Reference26 articles.

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