A systems-level analysis of bile acids effects on rat colon epithelial cells

Author:

Yde Jonathan1,Wu Qi1ORCID,Borg Johan F.1,Fenton Robert A.1ORCID,Moeller Hanne B.1ORCID

Affiliation:

1. Department of Biomedicine, Aarhus University, Aarhus, Denmark

Abstract

Feeding rats with a bile acid caused changes in fecal output, underlining this bile acid diarrhea model’s usefulness. Colonic epithelial expression of genes associated with facilitated transport of bile acids was altered during bile acid feeding. The study raises the possibility of regulated colonic transepithelial transport of bile acids in response to luminal bile acids. In addition, this study provides annotated rat colonic epithelial cell transcriptome and proteome with response to bile acid feeding.

Funder

Knud og Edith Eriksens Mindefond

Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat

STIBO Fonden

A.P. Møller Fonden | Fonden til Lægevidenskabens Fremme

Aage og Johanne Louis-Hansens Fond

Aarhus Universitets Forskningsfond

Carlsbergfondet

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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