Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2-Reference-Cited by-同舟云学术

Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2

Published:2023-11-01 Issue:5 Volume:325 Page:G446-G452
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Smyth Jessica S.¹^ORCID,Truong Jennifer K.²,Rao Anuradha²,Lin Ruxian²,Foulke-Abel Jennifer³^ORCID,Adorini Luciano⁴,Donowitz Mark³⁵^ORCID,Dawson Paul A.²^ORCID,Keely Stephen J.¹^ORCID

Affiliation:

1. School of Pharmacy and Biomolecular Sciences, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland

2. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Children’s Healthcare of Atlanta, Atlanta, Georgia, United States

3. Gastroenterology Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

4. Intercept Pharmaceuticals, San Diego, California, United States

5. Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Abstract

Activation of the nuclear bile acid receptor, farnesoid X receptor (FXR), specifically upregulates ACE2 expression in undifferentiated colonic epithelial cells and inhibits virus-induced proinflammatory cytokine release. By virtue of these actions FXR represents a promising target for the development of new approaches to prevent intestinal manifestations of SARS-CoV-2 infection.

Funder

HHS | National Institutes of Health

Science Foundation Ireland

NIDDK | National Institutes of Health

National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00099.2023

Reference28 articles.

1. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

2. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

3. Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19

4. Gastrointestinal Manifestations of COVID‐19: Impact on Nutrition Practices

5. Faecal calprotectin indicates intestinal inflammation in COVID-19