<i>Bacteroides thetaiotaomicron</i> and <i>Faecalibacterium prausnitzii</i> served as key components of fecal microbiota transplantation to alleviate colitis-Reference-Cited by-同舟云学术

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii served as key components of fecal microbiota transplantation to alleviate colitis

Published:2024-05-01 Issue:5 Volume:326 Page:G607-G621
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Xu Binqiang¹²,Fu Yang¹²,Yin Nuoming¹²,Qin Wenfei¹³,Huang Zehua¹²,Xiao Wei¹³,Huang Huizhen¹⁴,Mei Qixiang¹²,Fan Junjie²,Zeng Yue¹²^ORCID,Huang Chunlan¹²^ORCID

Affiliation:

1. Shanghai Key Laboratory of Pancreatic Diseases, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China

2. Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China

3. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People’s Republic of China

4. Shanghai General Hospital of Nanjing Medical University, Shanghai, People’s Republic of China

Abstract

We demonstrate that donors with high abundance of Bacteroides and Faecalibacterium ameliorate dextran sulfate sodium (DSS)-induced colitis in mice by fecal microbiota transplantation (FMT). The combination therapy of Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii is superior to mono-bacterial therapy in ameliorating colitis in mice, of which mechanism may involve promoting lecithin and inducing IL-10 production of intestinal Tregs.

Funder

Songjiang Science and Technology Committee

Shanghai Jiao Tong University School of Medicine, Digestive Institute

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00303.2023

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