Maternal high-fat diet activates hepatic interleukin-4 in rat male offspring accompanied by increased eosinophil infiltration-Reference-Cited by-同舟云学术

Maternal high-fat diet activates hepatic interleukin-4 in rat male offspring accompanied by increased eosinophil infiltration

Published:2021-01-01 Issue:1 Volume:320 Page:G81-G92
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Wang Huan¹,Xu Guanying Bianca²,Chen Hong¹³,Pan Yuan-Xiang¹³²^ORCID

Affiliation:

1. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois

2. Illinois Informatics Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois

3. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois

Abstract

The present study identifies that maternal high-fat-diet-induced IL-4 upregulation is associated with DNA hypomethylation at the +6 kb region of the 3’ downstream region of the gene. Furthermore, our results confirm that the induced Il4 expression in the liver of male offspring corresponds to the induced immune cell, especially eosinophil, infiltration.

Funder

UIUC Research Board Grant

University Library at the University of Illinois at Urbana-Champaign data purchasing grant

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00153.2019

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