Maternal high-fat diet activates hepatic interleukin-4 in rat male offspring accompanied by increased eosinophil infiltration

Author:

Wang Huan1,Xu Guanying Bianca2,Chen Hong13,Pan Yuan-Xiang132ORCID

Affiliation:

1. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois

2. Illinois Informatics Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois

3. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois

Abstract

The present study identifies that maternal high-fat-diet-induced IL-4 upregulation is associated with DNA hypomethylation at the +6 kb region of the 3’ downstream region of the gene. Furthermore, our results confirm that the induced Il4 expression in the liver of male offspring corresponds to the induced immune cell, especially eosinophil, infiltration.

Funder

UIUC Research Board Grant

University Library at the University of Illinois at Urbana-Champaign data purchasing grant

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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