Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms-Reference-Cited by-同舟云学术

Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms

Published:2022-08-01 Issue:2 Volume:323 Page:G61-G70
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Voigt Robin M.¹²³^ORCID,Zalta Alyson K.⁴⁵,Raeisi Shohreh¹,Zhang Lijuan¹,Brown J. Mark⁶⁷⁸⁹,Forsyth Christopher B.¹²³,Boley Randy A.⁵,Held Philip⁵,Pollack Mark H.⁴,Keshavarzian Ali¹²³¹⁰^ORCID

Affiliation:

1. Rush Center for Microbiome and Chronobiology Research, Rush University Medical Center, Chicago Illinois

2. Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois

3. Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, Illinois

4. Department of Psychological Science, University of California, Irvine, California

5. Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois

6. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio

7. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio

8. Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio

9. Center for Microbiome and Human Health, Cleveland Clinic Foundation, Cleveland, Ohio

10. Department of Physiology, Rush University Medical Center, Chicago, Illinois

Abstract

This study confirms an abnormal intestinal environment is present in subjects with PTSD. This study adds to what is already known by examining the intestinal barrier and evaluating the relationship between intestinal readouts and PTSD symptoms and is the first to report the impact of PTSD treatment (which improves symptoms) on intestinal readouts. This study suggests that targeting the intestine as an adjunct approach could improve the treatment of PTSD.

Funder

Philanthropic funding from Mr. and Mrs. Larry Field, Mr. and Mrs. Philip Glass, the Sylar family, Chuck and Joan Johnson, and Harlan Berk

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

HHS | NIH | National Institute on Aging

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00066.2022

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