Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson’s disease-Reference-Cited by-同舟云学术

Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson’s disease

Published:2024-02-01 Issue:2 Volume:326 Page:G195-G204
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Sawamura Tomoya¹,Yuki Natsufu¹,Aoki Kanae²,Horii Kazuhiro¹³,Horii Yuuki⁴,Naitou Kiyotada⁵^ORCID,Tsukamoto Shumpei¹,Shiina Takahiko¹²,Shimizu Yasutake¹²⁶^ORCID

Affiliation:

1. Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan

2. Department of Basic Veterinary Science, Laboratory of Physiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan

3. Division of Biological Principles, Department of Physiology, Graduate School of Medicine, Gifu University, Gifu, Japan

4. Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan

5. Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

6. Division of Animal Medical Science, Center for One Medicine Innovative Translational Research (COMIT), Gifu University Institute for Advanced Study, Gifu, Japan

Abstract

In a rat model of Parkinson’s disease, the component of descending brain-spinal pathways that regulate colorectal motility through a mediation of the lumbosacral defecation center was altered from stimulatory serotonergic neurons to inhibitory GABAergic neurons. Our findings suggest that chronic constipation in Parkinson’s disease patients may be associated with alterations in central regulatory mechanisms of colorectal motility. The plasticity in the descending pathway regulating colorectal motility may contribute to other disease-related defecation abnormalities.

Funder

Japan Society for the Promotion of Science London

Ministry of Education, Culture, Sports, Science and Technology

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00181.2023

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