Affiliation:
1. Department of Surgery, University of California Los Angeles, Los Angeles, California, United States
Abstract
Chymotrypsins defend the pancreas against the inflammatory disorder pancreatitis by degrading harmful trypsinogen. This study demonstrates that mice devoid of pancreatic chymotrypsins are phenotypically normal but become sensitized to secretagogue hyperstimulation and exhibit increased intrapancreatic trypsin activation, more severe acute pancreatitis, and rapid progression to chronic pancreatitis. The observations confirm and extend the essential role of chymotrypsins in pancreas health.
Funder
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
Hirshberg Foundation for Pancreatic Cancer Research
National Pancreas Foundation
U.S. Department of Defense
Publisher
American Physiological Society